Silver Nanoparticles Self-Assembly

SERVICE NO:

The prerequisite for the application of silver nanoparticles is to ensure the stability of the nanoparticles and the possibility of surface chemical modification. Many methods for assembling metal nanoparticles have been developed to meet the demand for two-dimensional and three-dimensional plasma devices. The traditional self-assembly of nanoparticles is mainly a process in which nanoparticles spontaneously organize or aggregate into a thermodynamically stable, uniformly distributed and special performance structure. This process mainly relies on two factors to form the aggregation system: one is to form a stable nano-aggregation system through non-covalent bond (especially hydrogen bond) interactions; The second is the spontaneous aggregation of the nanosystem to reach a low energy level. However, due to the reliance on non-covalent bond interactions or intercharge interactions, the nano-aggregation systems obtained through these traditional methods often exhibit poor repeatability and stability, which restricts the application of materials in biological systems.

BOT Bioscience selects appropriate methods based on different customer needs and provides customers with comprehensive nano-ion self-assembly services.

Service Methods

The self-assembly of nanoparticles can mainly be carried out in two ways. One is to modify appropriate chemical ligands on the surface of nanoparticles to mediate their self-assembly. The second is to construct nanoparticles that respond to endogenous or exogenous stimuli to trigger their self-assembly.

1. Chemical modification mediates self-assembly

A wide variety of chemical ligands can be modified on the surface of nanoparticles to mediate self-assembly and aggregation, such as small molecule compounds, polymers, and biomacromolecules, etc.

2. Solvent evaporation and self-assembly

The solvent evaporation self-assembly method utilizes the weak intermolecular forces, electrostatic attraction or their interaction with the matrix between nanoclusters or cluster compounds. Through the evaporation of the solvent, they spontaneously assemble into regular, ordered structures or superlattices.

3. Template method

When assembling nanoparticles using the template method, due to the recognition effect between the selected assembly template and the nanoparticles, the template has guiding significance for the assembly process, making the assembly process more complete. The selected templates can be solid matrices, single-layer or multi-layer membranes, organic molecules or biomolecules, etc. Under normal circumstances, the template used to assemble nanoparticles is also a surfactant or stabilizer that controls the growth of nanoparticles. The protective and restrictive effects of the template can enhance the stability of nanoparticles.

Influencing Factors

1. pH stimulation

Among the numerous internal environment stimuli of organisms, pH is one of the important inducements. Under acidic pH conditions, the surface modification of nanoparticles undergoes hydrolysis, causing the surface of nanoparticles to carry positive and negative charges, and electrostatic interaction leads to the aggregation of nanoparticles.

2. Enzyme stimulation

For the self-assembly aggregation system of nanoparticles responsive to enzyme stimulation, it is necessary to modify substrate peptides that can be specifically cleaved by enzymes on the surface of nanoparticles.

3. Other endogenous stimuli

Other endogenous stimuli that can trigger the self-assembly and aggregation of nanoparticles mainly include metal ions, REDOX substances, etc. Sodium chloride salt can neutralize the electrostatic interaction between citrate modified nanoparticles, causing strong van der Waals forces between nanoparticles to aggregate. Hydrogen peroxide stimulates PEG cleavage on the surface of responsive nanoparticles, exposing hydrophobic ligands and causing self-assembly and aggregation of nanoparticles.

Service Advantage

? Service-oriented: Reasonable prices, and comprehensive analysis based on customer needs can be conducted to provide satisfactory results for customers.

? Professional technical support: We guarantee strong, considerate and timely pre-sale and after-sale service support to answer any questions you may have.

? Complete upstream and downstream services: Provide one-stop technical services such as nanoparticle preparation and modification, saving customers' precious time.

Service Process

After both parties reach an agreement through communication, the experimental plan is determined, the service requirements are set - the contract is signed - the advance payment is made - the experiment begins - the results are delivered