Mouse Anti-Rat CD44H Antibody (Clone OX-49), FITC
| Cat.No. : | BIOS-2210F |
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| Species : | Rat |
| Source : | Mouse |
| Clone : | OX-49 |
| Conjugation : | FITC |
| Application Note : | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results (Clone The recommended concentration is 0.1-1 ug/106 cells in 100 μL volume). |
| Format : | Liquid |
| Purity : | >90% |
| Concentration : | Please refer to the vial lable for the specific concentration. |
| Buffer : | Supplied in PBS, pH 7.4. |
| Purification : | SDS-PAGE |
| Molecular Weight : | 150kd |
| Antibody Isotype : | IgG |
| Storage : | Store at -20 degree for long term. |
| Background : | CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope. |
| Keywords : | CD44H |
| Synonyms : | Pgp-1; H-CAM; CD44s; CD44H |
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