Infectious Disease Proteins
Overview
Bot-Bioscience’s Infectious Disease Proteins refer to the protein molecules directly related to the occurrence and development of infectious diseases - these proteins may be produced by pathogens (such as bacteria, viruses, fungi, etc.) or abnormally expressed by human host cells after infection, and their functions directly affect the transmission, pathogenic mechanism of infectious diseases or the immune response of the host.
The core of infectious disease proteins can be divided into proteins derived from the pathogen and proteins derived from the host. These two types play crucial roles in different stages of infectious diseases. Core classification: Proteins derived from the pathogen and proteins derived from the host, both of which play key roles in different stages of infectious diseases.
Proteins derived from the pathogen source
Virus Type | Key Protein |
Novel Coronavirus | Spiketron protein (S protein) Nucleocapsid protein (N protein) |
Influenza Virus | Hemagglutinin (HA protein) Neuraminidase (NA protein) |
HBV | Surface antigen (HBsAg) E antigen (HBeAg) |
The proteins encoded by the pathogens (such as viruses and bacteria) themselves are the core "tools" for them to infect hosts, damage tissues, and evade the immune system. They are also the core targets for vaccine and drug development.
Host-derived proteins
After being infected by pathogens, human cells will abnormally express or regulate certain proteins. These proteins may be involved in "immune defense" (to fight against pathogens), or be utilized by pathogens (to promote infection), or cause "immune damage" (to aggravate the condition) due to excessive activation.
1. Host proteins involved in immune defense, including antibodies and cytokines.
2. Host proteins that are exploited by pathogens. The pathogen needs to rely on host proteins to complete its replication. These host proteins are called "virus/bacteria-dependent factors", such as the ACE2 protein.
3. Host proteins that cause immune damage. The severe symptoms of some infectious diseases are caused by the host's excessive immune response, which leads to "self-injury". The relevant proteins are the key mediators.
Application Type | Common Application Scenarios |
Vaccine Development | The core components of most vaccines are "pathogen antigen proteins" (such as the S protein of the COVID-19 mRNA vaccine and HBsAg of the hepatitis B vaccine), which induce the body to produce antibodies and memory cells, thereby achieving the prevention of infectious diseases. |
Research and Development of Drugs | Oseltamivir (inhibits the NA protein of influenza)、Nematrevi (inhibits the 3CL proteinase of the novel coronavirus),Maravero (blocks the binding of HIV to the host's CD4 protein). |
Qiagnostic Reagent | By detecting the proteins of pathogens or those related to the host, infectious diseases can be diagnosed quickly. |
Application Scenarios
To learn more about our products, please search through keywords or contact us via email at info@bot-bioscience.com. We are looking forward to assisting you in finding the most suitable infectious disease protein for your research.
Products Highlights
Extremely high security, no risk of infection
Precise immune response and strong protective efficacy
The production process is controllable, can be scaled up, and has high stability.
High specificity, suitable for various application scenarios
