Rat Anti-Mouse IL-17A Antibody (Clone 17F3), PE/Cyanine7

Cat.No. : BIOS-1997F
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Species : Mouse
Source : Rat
Clone : 17F3
Conjugation : PE/Cyanine7
Application Note : Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Format : Liquid
Purity : >90%
Concentration : Please refer to the vial lable for the specific concentration.
Buffer : Supplied in PBS, pH 7.4.
Purification : SDS-PAGE
Molecular Weight : 150kd
Antibody Isotype : IgG
Storage : Store at -20 degree for long term.
Background : The 17F3 monoclonal antibody reacts with mouse IL-17A a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. IL-17A has pleiotropic effects in immunoregulation and inflammation. It plays an important role in anti-microbial and chronic inflammation by inducing cytokine and chemokine production, neutrophil influx, and the production of antibacterial peptides but it is also an inflammatory mediator in the development of autoimmune diseases including rheumatoid arthritis, asthma, multiple sclerosis, and psoriasis. The 17F3 antibody has been shown to neutralize IL-20A in vivo.
Keywords : IL-17A
Synonyms : Interleukin-17A; Il17a; Ctla8
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