Rat Anti-Mouse IL-17A Antibody (Clone TC11-18H10.1), APC

Cat.No. : BIOS-2017F
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Species : Mouse
Source : Rat
Clone : TC11-18H10.1
Conjugation : APC
Application Note : Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Format : Liquid
Purity : >90%
Concentration : Please refer to the vial lable for the specific concentration.
Buffer : Supplied in PBS, pH 7.4.
Purification : SDS-PAGE
Molecular Weight : 150kd
Antibody Isotype : IgG
Storage : Store at -20 degree for long term.
Background : IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
Keywords : IL-17A
Synonyms : Interleukin-17A; IL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; CTLA8
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